Originally Posted by Retro Grouch

How picky are you? If you dig deeply enough you can find reasons for almost anything.

1. Need the computer magnet on the correct side.
2. Many wheels aren't dished perfectly so the brake might rub if the wheel is installed backward.
3. Directional tire tread.
4. Traditionally the QR lever goes on the left.
5. Traditionally unidirectional printing should be readable from the right side.