Hiya,
I'm not sure what changes to make to saddle height or orientation. I have a Giant OCR2 and have had no issues that way.
However, from reading your posts and looking over your website, I do know that you ride a ton of miles. You might consider adding some hamstring bench work to your routine. Your quads are likely stronger than heck and that can create an inbalance overpowering the hammies. This was precisely the kind of solution that I used. I found that my hammies were often sore or tight, particularly after doing my lunch time runs. Since I work at a high school, I spoke with the trainer who suggested I hit the bench.
Since I have been doing a once a week session at the gym (light weights but many reps), much of that discomfort has gone away. Just a thought.
Sheldon
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