I had to try a number of them before I found one that 'worked', the only problem is it took me a LOT of miles to find if it worked or not! I found that, for me, the best ones were rather hard, no padding whatsoever other than the leather covers. The only exception to this was the last one I tried- which I REALLY like now- It is a F-1 from nashbar. First one that I've tried with a cutout, and I really like it- at least as well as some of the $100+ ones with fancy Italian names that I've tried.
I've also found that it's a combination of things- A good saddle, properly adjusted, and proper riding attire- If I'm putting on serious miles, baggies just don't cut it!
I am lusting after a brooks saddle now- Might have to try that route for the next bike... Seems like there are a LOT of happy owners out there