Any activity that involves gripping or moving the fingers while the wrist is bent can cause problems. Carpal tunnel syndrome (CTS) is ugly, and can end careers. CTS is probably my problem, and I am trying to manage it because I do not want a worker's comp situation. I wear a carpal tunnel brace on my right arm when I sleep and much of the time while awake. I have not noticed cycling to aggravate my situation, but I try to always be careful to keep my wrists in a neutral position while riding.