I only have 3 ways to do this:
1-Get a Mini Velo with S&S Couplers and have a slightly above average road bike quality ride with a below average travel capability
2-Get a folding bike that is not a Brompton and have an average road bike quality with an average travel capability
3-Get a Brompton and have a below average road bike with the highest travel capability.
I am honestly more inclined towards 1 or 3, so Bike Friday is not a good fit for me. I am strongly considering an S6 with BWR as my only bike.
I would go for the mini-velo with S&S couplers, simply because 406mm tires and rims are easier to find than brompton 16". That and the brompton is not as adjustable, meaning you will be less comfortable on longer distances.