Three years ago, I started cycling in earnest and increased my saddle time substantially. After about 6 months of near-daily cycling, I came down with a (thankfully brief) case of prostatitis - believe me when I tell you that this is no fun.
Determined to do what I could to avoid this, I switched to a Spiderflex saddle. It definitely took some getting used to and adjustment (the first few weeks were rough), but after two years of regular use, it's quite comfortable. In fact, I just finished using it on a weeklong, 350-mile bike tour. I have no problems with control of the bike, even with loaded panniers; on smooth roads I can still ride hands-free.
Most importantly, since I switched to the Spiderflex, no more issues "down under" - no numbness, pain, nothing.