I have a hybrid and I took a more drastic approach that was almost excessive. I mean I put on 700x45 Kenda Keen Commuter tires (which I found out was way, way too much, could have settled for something from 37 to 42), a Velo Plush saddle with springs underneath and I already had a suspension seatpost. Now I can't feel a darn thing.
Now, I almost can't wait to complete my touring bike because I'd like to know what it's like to feel SOMETHING rather than nothing.