Oh, man! There is an abundance of great riding in the area.
Most of the riding I did in that area was south of there but I'll bet you can find plenty of nice rides to the north also.
I liked to stay down around Maryville and Townsend and ride around there. One of my all time favorite rides is from Townsend up to Cades Cove and do a loop or two before coming back. The auto traffic around the Cove can be heavy in spots (really slow though) but I had good luck by getting up there early.
Member VeloVol posted a ride I really want to do. The Cherohala Skyway. Here's a link:
http://www.cherohala.com/