What would affect the comfort of a bike beside a good fit: lower air pressure, for most riders 90-100 lbs is fine; wider tires, 25 or 28, and if you are over 200 lbs I recommend 25 or at least on the rear tire as that carries 65% of the weight; a tall head tube; a longer wheelbase, and regarding a fork, going to a fork with a longer rake "more angled". Another idea is replace the seatpost with a shock absorbing seat post, and replace the handlebar tape with a more cushioned tape, more cushioned gloves also.