I had a heart attack in Feb 2011. Cause break away plaque. I was put on a daily for 18 month regimen of plavix, simvastatin and 81mg aspirin. On simvastatin I had horrible muscle fatigue. Some days I could hardly ride for an hour. As soon as I went off I was back to normal. My cardiologist now has me on pravastatin and I'm experiencing no side effects. I'm on the way back to being race ready. We all react to drugs differently.