are you talking about through axles? if so, they are pretty awesome. much stiffer than a quick release, and they are not a pain to take off at all, they come off similar to a quick release (if you don't have one, you can get a maxle, which is a kind of quick release through axle). many bikes today have a through axle in the front, and the trek remedy 9 has both front and rear through axles and i could tell the difference.
if you are going to have a tubeless set up, you aren't going to have to worry about flats, and if you just want to be able to take the wheel off and on, again, it's quite simple.