I'm fortunate enough to be able to handle my critical daily work remotely. I carry a small (Asus) laptop. The laptop lets me connect to my office PC so I have access to all my applications and documents. My only restriction (other than the extra 3.75 lbs in my panniers) is that I find internet access each day for about an hour. (In a pinch, I can connect my laptop to the internet via my phone [if I have cell service].) Work does accumulate when I'm on a tour, but I can go for 2-3 weeks before I need to get back and dig through it.