Originally Posted by
chaadster
Sounds like you might need to inspect the tire carefully. There could be an embedded object causing the punctures. Using your thumbs on the tread face, work your way away around the tire, pushing the inside of the casing up, and look for a tiny, sharp point. Could be glass, wire, metal shaving, etc.
You don't really need another post here, but I think this is the key. Whenever you have multiple punctures in the same area (two could be coincidence; three, probably not), you're likely to be missing something. I've had repeated flats from tiny pieces of wire or points of thorns that were almost invisible, so small I missed them even running my finger right over them. Check carefully.
One tip: when you install a tire, line up its label with the valve hole in the rim. If you do that every time, then when you find a puncture in the tube, you'll know where to look in the tire for the offending object. Saves some time.