200mg Celebrex daily for my back and other issues for near 16 years. Went off it for a few months and was fine, but started back up for post surgery inflammation control(trigger finger and carpal tunnel releases). I then developed SI induced Sciatica and have been back on the Celebrex since. Liver is fine and no ulcers or other side effects. Take a low dose aspirin daily because of heart history in the family(diabetes increases chances as well).