Specialized Secteur-i test road an apex version that on sale was ~$1100. very very comfortable and soaked up the bumps. down side to me it was but ugly and the ride was uninspiring. but the most comfortable i have ever been on a road bike
Giant Defy- a smooth ride and somewhat nimble. it was the bike i wanted to get but just couldn't catch one on sale.
if your looking for comfort and being upright Trust me take a test ride on the Specialized Sectuer, if you do buy it IIRC it can fit 28 tires then you will have a buttery smooth ride.
good luck