fwiw, cannondale has always put an emphasis on the frame over the components. How that holds up now that the aluminum frames have thousands of miles and multiple owners is a bit of a crapshoot. Inspect the bike closely when purchasing.
no matter what the frame, look for a seatpost in 26.8 or 27.2 and english BB threading, the rest is pretty easy [standard] from there.
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Shimano : Click :: Campy : Snap :: SRAM : Bang