38s are the sweet spot for me, having tried 24-38-50 in the last few years, and so i agree with mr yacht...if you don't need 50s for racing aero purposes, they tend to buffet me around on the really windy days, more than i prefer...but they do look cool...and maintain speed a little better once you get it going fast....but i especially like the fact that i can get ultralightweight wheels at 38 depth
I think 38mm is the sweet spot for a front wheel.
50/38 would be my choice.