I have a personal guideline for 700c wheels where I try to keep the separation of the two parallel spokes no more than 3" or so at the hub. That means reducing the number of crosses when using ultra large flanges. By the same token, smaller rims call for smaller separation at the hub.
If you want a rough guideline, keep spoke separation at the hub smaller than the 1.5x the distance between the same spokes at the rim, preferably nearer to 1x that distance.
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