I'm running a disc trucker with "wheels for the apocalypse". I built it up myself for the most part.
PW 48 sp disc tandem hubs and velocity Chucker rims and marathon 38's (a 420 on front, and a plus on the rear)...
Expensive definitely, Over kill perhaps, reliable? Hell yes....
Gross vehicle weight rarely exceeds 350, but I did have it airborne while loaded once at about 20 mph.