I'm putting together my new touring bike right now. A few thoughts:
- I went with MTB hubs (Shimano XT) -- those are the ones with the 135mm spacing you need on a touring frame. I'm not sure you can find 105 hubs in 135mm.
- I used a Sugino crank. It's really purdy and dirt cheap compared to most road components. Otherwise I would recommend a MTB crankset because it gives you real-world touring gears. My "other bike" is a 53/39 ultegra 10spd double which I really enjoy but I didn't think twice about going to a 46/36/24 for the tourer.
- I opted for Cantilever brakes, but you'll enjoy the disc brakes too. I like the classic look of the canti's and I've never had trouble with stopping power.
My wife has the 2004 OCR touring bike. She likes it fine although it was hard to find a rack that fit well (she's a really small frame) and the rack/bags do come very close to interfering with the disc brakes. YMMV because of frame size differences, etc.