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  1. #1
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    Benefit of testosterone

    Over at Daily Peloton forums, D-Queued gives a good precis of quick research on the academic studies that do actually exist on testosterone and athletic performance.

    http://www.dailypelotonforums.com/ma...showtopic=2779


    There have been extensive discussion of the benefits, or more precisely the lack thereof, of Testosterone in numerous threads.

    Much of this discussion is related to the Landis case, as well as the various assertions by the Landis camp in the ongoing PR campaign (albeit not incorporated in his legal defense statements). There have been further assertions that finding any information was also a difficult to impossible task. Thus, it made sense to investigate further and post whatever actual research could be found on the subject.

    Note that the research accessed here was neither difficult nor time-consuming to find. It involved simple search phrases such as "Testosterone performance in athletes". Far, far less time was reauired to to find this material than was required to actually type this post out. Some of it did cost me some money, but even that was minor. Moreover, the research all predates Stage 17 of last summer's Tour.

    As noted in an earlier post, there has actually been a lot of research on Testosterone. Much or most of the research has been related to health issues -- resolving Testosterone deficiency, etc., particularly in older individuals. Not surprisingly, there has not been as much scientific research into performance enhancement for medical/ethical reasons among others. The use of Testosterone is known to be 'rampant' within the sporting world, and one must conclude that such use reflects extensive experimentation, and hence research, within sport. The research on health-related benefits has indicated benefits that would support a top cyclists interest in Testosterone as an enhancement agent.

    Beyond those cited previously, such research includes(1)

    Anabolic steroids are testosterone derivatives with three mechanisms of action. First, anticatabolic effects reverse the actions of glucocorticoids and help metabolize ingested proteins, converting a negative nitrogen balance into a positive one. Second, anabolic effects directly induce skeletal muscle synthesis. Third, there is a "steroid rush"--a state of euphoria and decreased fatigue that allows the athlete to train harder and longer.

    All of which are completely consistent with Manzano's description of the benefit of Testosterone in his 2004 testimony about Kelme/Fuentes.

    With respect to research on Testosterone benefit in athletes specifically, there are at least three studies of note:

    A 1996 study (2) injected volunteers weekly over a period ten weeks with either 600 milligrams of testosterone enanthate or a placebo. Performance tests done at the end of this period showed the hormone had improved muscle size and strength in those doing strength training, and to a lesser extent in those who did not exercise. Strength increased in both testosterone groups, as well as in the exercise group receiving placebo, but was greater in the exercise group with testosterone than in the exercise group with placebo.(3)
    A 2001 study (4) looked at the effects of different doses, with testing conducted only at the end of the 20 week study. This study concluded that changes in leg press strength, leg power, thigh and quadriceps muscle volumes, hemoglobin, and IGF-I were positively correlated with testosterone concentrations, whereas changes in fat mass and plasma high-density lipoprotein (HDL) cholesterol were negatively correlated.

    A similar 2003 study (5) concluded that, "the effects of testosterone on muscle performance are specific; it increases maximal voluntary strength and leg power, but does not affect fatigability or specific tension. The changes in leg strength and power are dependent on testosterone dose and circulating testosterone concentrations and exhibit a log-linear relationship with serum total and free testosterone." In other words, it makes you stronger without fatiguing you.

    In 2004, a study was conducted in Australia that utilized low dosages and weekly evaluation over the six week duration. Dosages of testosterone enanthate were 3.5 milligrams per kilogram of body weight (e.g. below 350 mg dose) for six weeks and compared with a placebo group. Tests included a cycling power ouput test (increasing the relevance to this forum and cycling related benefit), and the results were striking.



    Discussion of the test and its results was provided in New Scientist(6):

    EVEN a low dose of testosterone can give athletes a big performance boost - and in a fraction of the time thought necessary

    There was, however, a dramatic improvement in the performance of the athletes taking testosterone. The most unexpected finding was that the greatest increases in muscle size and power occurred just three weeks into the trial

    Taking testosterone for short periods only, taking smaller doses, or doing both, would reduce the chances of athletes getting caught by drugs testers. "Athletes have probably already figured this out, and we are just confirming that scientifically," says Randall Urban of the University of Texas at Austin

    if athletes or coaches have learned by trial and error to use low doses for short periods only, there is less chance of them being caught. Their TE ratios should also return to normal faster, further reducing the chances of detection even under the new testing regime

    Hopefully this material sheds some light on the possibility of Testosterone use as a realistic short-term aid for cycling performance, even at low doses.
    Dave.
    (1) Haupt HA, Rovere GD. Anabolic steroids: a review of the literature. Am J Sports Med 1984;12:69-84.
    (2) Bhasin S, Storer TW, Berman N, Callegari C, Clevenger B, Phillips J, et al. The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men. N Engl J Med 1996; 335:1-7.
    (3) http://www.mja.com.au/public/issues/...y/kennedy.html
    (4) Bhasin S, Woodhouse L, Casaburi R, et al. Testosterone dose-response relationships in healthy young men. Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1172-81.
    (5) Storer TW, Magliano L, Woodhouse L, et al. Testosterone dose-dependently increases maximal voluntary strength and leg power, but does not affect fatigability or specific tension. J Clin Endocrinol Metab. 2003 Apr;88(4):1478-85.
    (6) Cohen, D. Cheating is easier than you think. New Scientist. August 2004, 2460: 6-7.

  2. #2
    Elitist Jackass Smoothie104's Avatar
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    I don't think Floyd knowingly took any synthetic testosterone before that stage.. But I do think he received some blood or redcells the night after his collapse, and before stage 17. Blood for the Tour is usually taken out immediatley after the Dauphine, or sometimes near the end of it.. He may have been banging the testosterone in after the Dauphine to get strong and primed for the TdF, and some of that may have made its way into the blood etc.. When the stored blood went back in, so did the synthetic testosterone.

    There's a three week time period between the 2 events, and for two of those weeks, you can take your Growth Hormone and EPO, testo, and LHS, or whatever the female fertility drug they use to mask the testo. And have the EPO out of your system prior to the Pre Tour Med check.. the Growth Hormone is still undectable..

    If you look at Tyler Hamiltons Documents seized in Operation Puerto, he was a human pin cushion during the time between the Dauphine and the TdF...
    "You should already be aware that riding with people who steer with their elbows, stick food to the top tube of their frames and ride around in dick togs is not a great idea." -- Classic1

  3. #3
    elitist jerk daytonian's Avatar
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    Smoothie
    HGH is undetectable to present tests? They must jack that hard if it cannot be detected. Just googling it shows how expensive it is comparitively to deca and test. Now wonder Ullie spent so much!
    I feel like a soiled kleenex dropped in the gutter in the red-light district of Paris.

  4. #4
    Senior Member sverrefehn's Avatar
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    Testosterone can also increase your hematocrit.

  5. #5
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    Quote Originally Posted by Smoothie104
    I don't think Floyd knowingly took any synthetic testosterone before that stage.. But I do think he received some blood or redcells the night after his collapse, and before stage 17. Blood for the Tour is usually taken out immediatley after the Dauphine, or sometimes near the end of it.. He may have been banging the testosterone in after the Dauphine to get strong and primed for the TdF, and some of that may have made its way into the blood etc.. When the stored blood went back in, so did the synthetic testosterone.

    There's a three week time period between the 2 events, and for two of those weeks, you can take your Growth Hormone and EPO, testo, and LHS, or whatever the female fertility drug they use to mask the testo. And have the EPO out of your system prior to the Pre Tour Med check.. the Growth Hormone is still undectable..

    If you look at Tyler Hamiltons Documents seized in Operation Puerto, he was a human pin cushion during the time between the Dauphine and the TdF...
    hi Smoothie

    remember the stage when Phonak rode on front and Floyd just tanked at Dauphine?

    I concede that they are peaking for 5 weeks later, and they have been in heavy training, but still, when does a tour winner, get pantsed by guys like Kohl and Hesjedal on climbs. those guys are obviously talented, but the tour winner must be strong enough to be able to go with those guys 5 weeks out.

    Makes you you wonder why his performance was so poor. He did timetrial well enough earlier though. But taking blood out DURING a tour is probably unique. But I think the 2005 Disco set a precedent when the team collapsed on the first intermediate mountain stage when Armstrong was isolated. Andreau and Vaughters said they had blood out after dauphine and 800mls infused after that stage in question.

    Obviously to have blood out AFTER Dauphine without the ability to atleast microdose EPO is not time enough for all the cells to regenerate in time for the prologue. BUT, this all relies on HOW MANY packets of blood are stored. If you have enough, no need to ride the prologue on less than packed hemoglobin ratio.

    The question is, how can tour riders tune their form and efforts in the last few weaks as they taper, when they are trying to ride on less cells and build up the cell count with microdosing, which is flirting with danger, as the vampires come testing urine not blood at anytime.

    Landis was very strong in the prologue, did they work out he was about effective 3rd place to Hinc and Thor? And he was strong in the first tt, within 40 seconds without mechanicals of Gonchar, who was obviously on something.

  6. #6
    Elitist Jackass Smoothie104's Avatar
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    The traditional pre TdF 2 week at a remote high altitude training camp helps...While the team must give their where abouts, being isolated helps delay or avoid the testers for a while, and maybe get a litte advance notice of thier arrival.
    "You should already be aware that riding with people who steer with their elbows, stick food to the top tube of their frames and ride around in dick togs is not a great idea." -- Classic1

  7. #7
    Senior Member Dubbayoo's Avatar
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    Quote Originally Posted by daytonian
    Smoothie
    HGH is undetectable to present tests? They must jack that hard if it cannot be detected. Just googling it shows how expensive it is comparitively to deca and test. Now wonder Ullie spent so much!
    Both HGH and IGF-1 (what HGH converts to in the body) are undetectable. There is a test for HGH but it is not reliable.

    By the way, if you know where to look a year's supply of testosterone can be had for less than the cost of a good pair of bib shorts. Same supply of HGH = less than a set of Mike Garcias.

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