Has anyone had experience with certain medications causing weight plateaus? Since I have been on Coumadin for a DVT in the calf, I have leveled out in weight and it is very hard to lose weight even with consistant cycling and diet. Before being on this medication I would drop weight very quickly when cycling. Is it possible for medications to effect actually how you burn calories, because something is definitely wrong here and the doctors say there is no side effect of weight plateau on this medication.