In St. Louis, the older, inner suburbs are not too bad. Webster Groves, Kirkwood, Shrewsbury, Maplewood, Richmond Heights. Anything outside the immediate inner ring is a nightmare, not that the city proper is that much better. It's all twisty, windy, sprawled subdivisions and 6-lane thoroughfares. There are side streets and dedicated bike paths, but nothing connects to anything. Where there are gridded street systems, the grid is broken all over the place by big box retail centers, barricaded neighborhoods, railroad tracks, highways.
The worst is the St. Charles area, where I grew up. Not only is it terrible for walking and biking, there are absolutely zero transit options.
To add to the nightmare, the only place to cross the Missouri river into St. Louis county that doesn't involve a car is on the 364 bridge, which is difficult to get to without using roads with heavy auto traffic, or poorly maintained back roads which are unsuitable for anything but a mountain bike. Except for downtown St. Charles and the fringes of the city, it's far from everything. People that live near the Katy trail or Creve Coeur park have an advantage, though. Those are the places the bridge connects on each side of the river. It's nice for recreational rides but totally impractical for regular transportation.