Its unusual to see muscle aching etc with Crestor - it, like Pravachol, bypasses the P450 cytochrome which contributes to the muscle problems we see with statins. Crestor is not usually a first line statin in people without CV disease. It's a super statin and for the most part is reserved for those who need VERY aggressive lipid lowering. The other "lab test" getting attention is hCRP. It is an inflammatory marker and being investigated as to whether it is a risk factor like high chilesterol and inproper diet is....