The number one issue is wheels for us heavier folks. I'm 350 and have ridden when I was your weight. Read the FAQs and ask where you want to ride. I would recommend a bike that you find comfortable with a thoroughly built up wheel on the rear. Many of us started with comfort or mountain bikes, but there is no reason to do so. Find a good bike shop and talk to an adult staff person (the kids are often not that helpful for us). Try some bikes and see what feels good. If a shop ignores you or tries to peg you as only a Mountain bike person, find another or talk to another staff member.
Find a bike that you find fun to ride!
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2007 TerraTrike Cruiser (XL) Trike
2004 Rans Stratus XL LWB Recumbent
1999 Trek Navigator 200 21"