The best road bike is the one that fits you and the one that you love to ride.
Everyone has their preferences, of course. I'm a sucker for Italian steel, even Italian steel handmade in Canada [I ride a Marinoni], and I know a lot of folks who swear by American titanium bikes.
Bicycles are so personal that there can't be any best.
Howver, these are some of the ones I would like to own...
De Rosa Corum [steel]
De Rosa Merak [Al]
Look KG381 [CF]
Marinoni Piuma [steel]
Wilier Triestina K2 [CF]
Empella Bonfire [Al]
Marinoni Fango [steel]
All would be built up with Campagnolo Record 10sp and Campagnolo Nucleon wheels, except the last two, which would have Record 9sp with wheels built from MAvic Open Pros.
Any questions?