Beiing that you stated you are at 255 I would stick with staright gauge spokes! 3x both sides and use spoke prep.
If you are having to adjsut tension evry 1000 miles or so it could be due to many factors. One you are a big guy and the biycle parts are designed for that 135lbs to 175lbs pro rider weight and not us bigger guys.
Now ask yourself would you use double-butted spokes and anything less than 3x spoke pattern on a loaded touring bike and expect the wheel to last 1000 miles? So why would you want to do it on a road bike wheel that is required to hold a 255lbs man who most likely wants to get up and sprint and ride hard. The touring bike has dead weight and the rider is just trying to get from point A to point B while you are most liley getting out of the saddle push it hard and more or less riding the hell out of it so whay gamble on some cool looking spoke pattern.
I would build your rear wheel with 14gauge DT or Wheelsmith non butted spokes, brass nipples and spoke prep and a good old common and trusted 3x pattern.