It depends on how severe your scoliosis is, and how much weight you'll have in the messenger-style bag. If it's mild scoliosis, which almost everyone has, and you don't plan to put an anvil in the bag, then you'll probably be fine. If not, then your back will let you know. But if you're concerned, then get a back-pack-style bag. It's far more comfortable, scoliosis or not.