Thanks for talking to me like I have never done anything athletic in my life
If you don't understand what I've posted then just ask for more baby talk.
My experience suggests that more often than not a "generalized" depletion of glycogen accounts for more experiential fatigue than specific muscularly generated metabolites or tissue damage when running on day after cycling. Of course I discount joint damage in making that statement.
So you got ask yourself - are you stupid, or just don't what your I'm talking about? There are plenty of tri-guys that run and ride almost every day, ask them for stories about when they were just getting started.
If all else fails grow up.