With only one bike you need to figure out the worst case scenario for riding. Do you ride in heavy rain? Do you haul groceries? Will EVER need rack and fenders?
For a non-racing bike, my view is that the weight penalty for threaded eyelets is so minimal and the extra utility so great that you should always get them. My ideal fast commuter road bike would be in the mould of a Soma ES, Surley Pacer. I wouldnt get too hung up abut frame material, they both work well when done well.
It is surprising how much you can haul on the road bikes if needed. You dont have to go all the way to a stodgy touring bike to get utility.