I CX bike on the road. A huge issue was cost and the Cross-Check complete was a real deal.
A big issue for me was getting the most versatility out of the bike as possible. Riding all winter, it was important that I be able to use studded tires which don't come in road varieties. Plus, I'm a larger guy (290# now 270#), so I knew I would need larger tires in order to get good rolling resistance without extraordinary tire pressures.
Oh yeah, and the cross-check is overbuilt and I have trashed enough frames to know that performance oriented top end weight weenie gear just doesn't work for big guys.