Moving the saddle forward will cause you to use your hamstrings and glutes less and quads more.
But it doesn't affect the calves much. To reduce the stress on them you can move the cleats back.
I'm 6' tall with a 35.5 inch cycling inseam. My saddle is at 78cm, but I tend to drop my heels when I pedal so it is a bit low. I'm about 1.5cm behind KOPS.
What's important is not what works for me but what works for you. I recommend starting from one of the formulas (i.e. LeMond) and moving things around one at a time to see what works for you. Make measurements and keep detailed notes. Or get a fitting.
Your problems may have nothing to do with bike fit- it could be that you have strained a muscle, have a back problem, need to stretch, or have a weak core.