If you have a biomechanical problem no amount of bike set up refinment will cure the problem, it may reduce the symptons.
Bike set up is not always the solution. Neither is exercise, posture, warm up or anthing else a solutions in them selfs all of the time.
For instance, if you have poor hip range of movement, lack of internal rotaional usually, then no bike set up is cabable of putting your knee in correct alinement. Patella malalinement issues often result from an outwards facing hip in an older athelets. Then the correct thing to do is work on the hip not the set up.
Bike set up is important, but occasionally seems to get over emphasised over other factors in these forums IMO.