I know the theory is that it saves weight in the wheel.
I doubt that this really true. The only effect of a low spoke count pattern or radial type lacing pattern is that you will have to use a heavier spoke to offset the strength lost due to fewer spokes.
With a 36 or 32; 3X pattern you can use a thinner spoke with severe butting if desired and I think the potential is that you can not build a sstronger but also lighter wheel.
Certainly I think your sacrifice in weight will be minimal.