For me, it's all about the fluids, since I only carry 2 bottles.
Depends on the weather - cooler temps and I don't go through my water as fast, and can get farther. If highs in the low 70's or lower, I can get by with just 1 stop. Higher temps and climbing/elevation definitely add to the water consumption. I think I stopped 5 or 6 times at DR, but I had heat, climbing, and elevation there.