Foo - Whatcha doin'?
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peregrine
02-27-06, 06:21 PM
Indeedie.
What's transgenic mice and what prep work are you doiong on them? You're not planning on sending them into outerspace are you :(
Transgenic mice are animals into whose genome has been inserted foreign/extra DNA. We're interested in a specific proteit and we want to see what are the effects of an abnormally high concentration of that protein. I'm not going to be making the mice, we have a core facility here on campus that does that because the technology required is very specific and expensive! But I have to prep the DNA. Unfortunately what we expect to happen to these mice is develop a skin disease with symptoms that resemble those of psoriasis :( :( :( Then we'll try to cure them :)
Psoriasis, huh? So you probably play with some immunosuppresants, either as the core of your work or as positive controls. Cyclosporin A, rapamycin, FK-506, or mycophenolic acid by any chance? When I was working at a biotech company (before going to grad school), I worked on cyclosporin A analogues. Boy was that difficult. Very hard to do anything useful with the molecule from a med chem point of view, and absurdly bad ADME properties. (Indeed, it's a classic example of a low water solubility low oral bioavailability substance.) Vague optimization goals. Expensive chemistry. Tough purifications. Boy was that a headache.
EDIT: Also, in the early 90's, my professor was the first to synthesize fully synthetic rapamycin. It's one of the more noteworthy total syntheses from that decade, and it defined a then novel macrocycle (large ring) forming strategy.
jyossarian
02-27-06, 06:43 PM
That's amazing!
[insert bunny pic here]
CycleMagic
02-27-06, 06:49 PM
the bunny with the pancake? HAHAHAHA i was thinking the same thing!
peregrine
02-27-06, 06:52 PM
Yes immunosuppresants are the main current treatment. Efalizumab is one of the newest ones, it's an antibody that blocks adhesion of T-cells and prevents their accumulation in the skin (which is the reason for the lesions). The problem is that these drugs only temporarily alleviate the symptoms. Once patients are off the treatment, they'll almost always experience rebound of the symptoms at eaqual or worse intensity (because all the T-cells that were held in the blood are now free to enter the skin. What we're trying to find is exactly what is the signal (protein) that activates the immune cells, and what's more - keeps them activated for abnormal periods of time. Then what we can do is generate an antibody that would specifically bind to and block that protein.
Antibodies... as a former med chemist, I see them and think "yum, protein". :p
jyossarian
02-27-06, 07:15 PM
I'm waiting for my dinner to cool and set.
http://static.flickr.com/39/105563013_f10acdb67d.jpg?v=0
Sorry, the image quality isn't all that good, but the camera that comes w/ a Palm isn't great in low light situations. BTW, it's a chicken pot pie w/ a chicken stock reduction sauce mixed with cream and a parmesan cheese crust.
UPDATE: Mmmm....gooooooodddd...[insert Homer Simpson drooling sounds here]
http://static.flickr.com/40/105578685_f0da46633b.jpg?v=0
peregrine
02-27-06, 07:18 PM
So you cooked that, jyo? Wow... ... can I adopt you???
TexasGuy
02-27-06, 07:19 PM
I'm waiting for my dinner to cool and set.
http://static.flickr.com/39/105563013_f10acdb67d.jpg?v=0
Sorry, the image quality isn't all that good, but the camera that comes w/ a Palm isn't great in low light situations. BTW, it's a chicken pot pie w/ a chicken stock reduction sauce mixed with cream and a parmesan cheese crust.
I'll umm take your word for it.
It doesn't look like anything I'd want to eat though :(
jyossarian
02-27-06, 07:19 PM
I cheated. I used frozen veggies and ready made pie crusts. But yeah, I'm up for adoption. ;)
jyossarian
02-27-06, 07:20 PM
I'll umm take your word for it.
It doesn't look like anything I'd want to eat though :(
Yeah, doesn't look pretty. But it tastes amazing.
TexasGuy
02-27-06, 07:21 PM
Does anybody recall the article that came out about (1 year ago) where they discovered some part of the gland that controlled the distribution of certain anti-body blood cells and they thought that if they could learn to control that then they could help people with muscular distrophy ? (I think)
TexasGuy
02-27-06, 07:22 PM
I have apple cinamon pieeeeeeeeeeeeeeeeeeeeeee
mmmm yummmmyyyy
Siu Blue Wind
02-27-06, 08:31 PM
I'm so happy.....oh so happy! :D
I'm so happy.....oh so happy! :D
No fair... you can't tell us something like that without explaining! :(
Im Tired.....Oh so Tired!
good night all!
jyossarian
02-27-06, 08:46 PM
I'm so happy.....oh so happy! :D
Vicodin? Ice cream? Vicodin & Ice cream? Sell another house? Caught the antenna thief? All of the above? Bicycle smile? :D
Siu Blue Wind
02-27-06, 08:50 PM
Vicodin....Oh I forgot to take that. Thanks for reminding me. Out of ice cream. No bicycle smile, too stormy to get Serenity wet.
Just thinking back on how the past few months have really been a blessing, that's all. :)
jyossarian
02-27-06, 08:55 PM
Vicodin....Oh I forgot to take that. Thanks for reminding me. Out of ice cream. No bicycle smile, too stormy to get Serenity wet.
Ummm...Serenity's your bike? or...
Just thinking back on how the past few months have really been a blessing, that's all. :)
How's that?
Im about to do my home work and go to bed.
Siu Blue Wind
02-27-06, 09:06 PM
Ummm...Serenity's your bike? or...
YES, SERENITY IS MY BIKE!!!!!! Geez, what else did you think Serenity was?
Trying to decide whether or not to move.
Our curent house has appreciated considerably. We could cash out, scale back and buy my in-laws' former house where my wife grew up, and be debt-free (except for the mortgage).
I hate the transaction costs and moving, but everything else makes sense...
jyossarian
02-27-06, 09:16 PM
YES, SERENITY IS MY BIKE!!!!!! Geez, what else did you think Serenity was?
I thought it was your bike too. Really. :rolleyes:
Siu Blue Wind
02-27-06, 09:22 PM
Okay Mr. Smartypants. Let's see how much you know me. What are the names of my other bikes?
^^^Siu, Blue, and Wind by any chance? I dunno, but I doubt your parents named you "Siu Blue Wind".
BeeTL, that's quite a decision you have to make! Good luck deciding.
Getting ready to set up one more reaction for the day. Happily, an overnight reaction.
Siu Blue Wind
02-27-06, 09:56 PM
What if I was Native American and Chinese?
Then that would definitely open up the universe of likely names. Whether or not you are, it would appear from your response that those aren't the names of your bikes.
jyossarian
02-27-06, 09:59 PM
Okay Mr. Smartypants. Let's see how much you know me. What are the names of my other bikes?
Easy. Melvin & Shlomo.
Siu Blue Wind
02-27-06, 10:05 PM
Now why would I call my bike "Easy?"
It's raining hard outside. I'm not going home yet, but I realized I forgot to drag along an umbrella. Oh well, whatever...
jyossarian
02-27-06, 10:12 PM
Now why would I call my bike "Easy?"
Cuz the other one's "Rider"?
Now why would I call my bike "Easy?"
I thought it was because the saddle gets play more easily than the rest of us.
Done with lab work for the day. Need to catch up on consulting work since I haven't done it since Friday. (In theory, I do my consulting work every day.)
MadMan2k
02-27-06, 11:31 PM
Gah. Calculating this stuff is hard.. "How many moles of sulfur are in 23.2g (C2H5)2S"
...
A couple :D
*now to find the actual number*
TheKillerPenguin
02-27-06, 11:31 PM
Procrastinating. Have a small essay due at 830 in the morning that I've yet to start.
TheKillerPenguin
02-27-06, 11:42 PM
Correction- I am now a sentence and a half into it. At this rate I'll be done by 10 :D
Gah. Calculating this stuff is hard.. "How many moles of sulfur are in 23.2g (C2H5)2S"
...
A couple :D
*now to find the actual number*
You figured it out yet? Generally, these types of problems are much easier if you meticulously keep track of units. You simply consider the units of the information you're given (or that are derivable from information given, for example, molecular weight of all molecules, any info on gases derivable from PV = nRT, and the like) and the units of the answer to the question at hand and ask yourself how to manipulate numbers so that you can transform one set of units to the other set of units.
For example, this problem simply is asking you to translate 23.2g of (C2H5)2S to x mol of S. Just multiply by a whole bunch of fancy-looking things that all equal one, and you'll get from one to the other. Keeping meticulous track of units may sound like hard work, but it allows you to determine with ease whether what you're doing is right since if you do something wrong (short of simply entering a wrong number), your units won't make any sense. And better yet, with a bit of practice, the units even tell you what manipulations to do. I never memorize how to solve such problems nowadays. I just let the units tell me what I have to do. If you need more explicit help, feel free to ask, but do so quickly since I'm headed home soon.
Wrapping up and getting ready to go home. It's been a long day.
I just tried to take a shower but there was absolutely no cold water! Everyone knows what it's like to take a cold shower, but taking a shower when the water is scorching hot is a lot worse! :eek: All I could do was kind of splash myself with water. Maybe I'll try again in the morning. For now, good night everyone. :)
At home now, eating a honey tangerine. Never bought them before. It seems decently good, though I prefer the ultra-sweet Mandarin oranges found at Costco. Need to write a check for rent, but otherwise, I'm done with any semblance of "work" for the night.
sunninho
02-28-06, 01:21 AM
Costco fruits are good! Tomorrow I will be a shopping fiend here: www.beveragewarehouse.com :D :beer: I plan to stock up on some sipping wine, shiraz and pinot griot, and maybe some foreign beer.
CycleMagic
02-28-06, 04:59 AM
Yeah, doesn't look pretty. But it tastes amazing.
i thought you made a giant chocolate chip cookie for dinner! (first pix). What is for dinner tonight?
Sitting at my desk drinking coffee (I hope you were all sitting down as I know what a shock that will be) and wondering how much award stuff I need to write now that the award stuff is part of the bike lit package. *sigh*
dragracer
02-28-06, 07:34 AM
Just having a cup of Java to wash down the free Fat Tuesday pancakes I just finished. Entertaining the thought of actually doing some work now. :)
TexasGuy
02-28-06, 07:38 AM
Rent is paid and i just received 2 checks which cover next month's expenses. w00t w00t. Now i need to start busting my ass on 5+ different projects :(
jyossarian
02-28-06, 07:50 AM
i thought you made a giant chocolate chip cookie for dinner! (first pix). What is for dinner tonight?
Leftovers. I made so much filling that I ended up w/ 2 pot pies. Got half of one plus a whole other one.
TexasGuy
02-28-06, 07:52 AM
Apple Cinnamon Crunch pie. MMMMMMMMmmmmmm yummy. Got some pork roast left over too :D Need to make me some mashed potatoes, and gravy and veggies.
jyossarian
02-28-06, 07:59 AM
mmmm....roast garlic smashed potatoes w/ bacon...mmmmm....
Siu Blue Wind
02-28-06, 10:48 AM
Well, gotta get ready for work. I'll see you guys tonite.
mmmm....roast garlic smashed potatoes w/ bacon...mmmmm....
*sigh* Take out the bacon and that sounds yummy. Now I'm hungry. Darn it. I have never been so hungry in my life since starting to read this thread.
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