I used to use Wheel Smith spoke prep with every build, it helps keep the nipples from loosening. It is expensive for one build, close to $40 for two little bottles.
Now I use Spoke Freeze from DT, it appears to be dilute loctite. Works well, you put it on after the build and let it wick into the threads.
With the spoke prep you have to apply just a bit to each threaded end, roll it into the threads and let it dry. If you apply it and can't assemble the wheel for a while the stuff gets pretty hard and makes the build more difficult.
I lube the nipples with triflow mostly. I use a little grease on the nipple holes if the rim does not have eyelets.
I have built wheels with no threadlock with no problem, if the tension is high enough(correct) they will not unscrew, but I prefer the insurance of threadlock
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I am in the woods and I have gone crazy.