I'm used to the rear tire wearing at a much more rapid rate than the front, particularly given my weight. With my new frame, it seems that the rear tire is wearing a lot faster than with previous bicycles. After about 1,000 miles, there is enough flat spotting that I'm about ready to change the tire out. In my old days of 10,000 mile training years, I can't recall changing the rear (clincher) tire out any more often than every 5,000 miles or so.
Maybe its just a particularly soft rubber compound, but it does make me wonder if there could be some misalignment of this frame which causes increased rear tire wear. Is that a common finding with a poorly aligned frame? Rear wheel is well centered between the stays with axles hard against the rear of the dropouts, FWIW.