As far as it bb sticking out, if the 'chain line' is straight, and the pedals spin without hitting the frame, there is no problem. I guess there may be fit issues with the angle your legs make when riding, but that is beyond my low level of wisdom.
2000 Montague CX, I do not recommend it, but still ride it.
Strida 3, I recommend it for rides < 10mi wo steep hills.
2006 Rowbike 720 Sport, I recommend it as an exercise bike.
1996 Birdy, Recommend.
Wieleder CARiBIKE (folding), decent frame.