I bought a new tire for my commuter bike, and it turns out the wire bead has a very noticeable kink in it:
The other bead is kinked as well, though not quite as badly. The tire is a 700x28 Specialized Nimbus (cheap-o road tire), in case it matters.
A. Install the tire and not worry about it
B. Try to un-kink the bead by bending it back
C. Throw it away