Dura Ace 7800 drivetrain.
When I'm out on the road with the wind shrieking in my ears, traffic, bumps & other distractions, I cannot sense it, but when I'm on my rollers, I feel (but do not hear) a very faint grinding feeling from my BB or possibly chain.
It only occurs on the small chainring and on the smaller rear cogs. (The closest I EVER come to cross-chaining is 39-14 (two small cogs are off-limits when on small chainring).) I can minimize it by focusing on perfect, fluid form and high cadence, but it's always there.
Until I shift onto the large chainring, then it disappears completely! Even when on my third-largest cog. (i.e. the closest I get to cross-chaining the other way.)
Chain wear doesn't appear to matter. It has occurred on my last three chains, and with different cassettes. I currently use an SRM crankset, but it also occurred with my OEM Dura Ace crank.
The BB doesn't appear to be the culprit--if I remove the pedals, the cranks spin completely freely (we're talking a dozen or more spins after I stop manually spinning it) and there is no noise or grit whatsoever.