Join Date: Oct 2007
Location: West Yorkshire, United Kingdom
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As bradtx notes, there main issues will be with the dropout size, and the max tire width the frame can take.
All a hybrid really is; or started of as, is a road bike, with a flat bar, instead of drops, and possibly wider tires & slightly more up-rite riding position, although the idea seems to be pretty fluid with what else goes on with them
Most 'hybrid' wheels will be 700c, and will be designed for 23-32mm tires, where as road normally use 23-25, so there is some crossover, on my hybrid I used road rims, with 23-28mm tires with no issues.
What type of touring are you intending to do, is important here, if credit card, then a normal road wheel will do, if heavy duty, then you would probably want to use tires bigger then a road frame can take, so the wheel would be a non issue there; if inbetween a 32/36 hole hub on say a Mavic Open Pro will do for light weight touring with upto 28mm tires.