Just replaced a tube in my rear tire with a new tube. The rim is essentially perfectly true.
The tube was well centered in the tire. I blew it up a little, and set it in the tire and made sure it was uniform all around with no redundant regions. I made sure the beads were set. Kept blowing it up a little bit at a time and rechecking everything. When I blew it up all the way it has a pretty good egg. Maybe 7-8 mm.
Is there such a thing as tire fatigue?