I've just had it with the stock saddle on my LeMond Buenos Aires. I knew it was a bit hard and uncomfortable when I bought the bike, but after the last time I rode, it has to go. I'll spare you all the gory details, but it has to go.
I saw the Selle San Marco Azoto TriathGel saddle on a Tri bike at my LBS. It looked far more comfortable, and I've read a few good reviews online. It especially interests me since I spend a lot of time both sitting and cruising on group rides with friends, time down in the drops, and like to sit toward the front of the saddle and spin at times -- all things that would bring the gel-padded nose of the Azoto TriathGel into play.
So, I am asking for your honest experiences with that or other saddles, especially if you are a larger-than-normal cyclist. For the record, I am 6-0, 230 lbs and ride a 51cm LeMond Buenos Aires. (It's that small because I have short legs: 30-inch inseams.)