I have about 500 miles on my Specialized Roubaix Elite and its Alex ALX 298R wheels. I can't really be much happier with the bike, or much less happy with the wheels. I've already had to get the rear wheel trued twice. A friend took pity on me and loaned me his 10 year old bomber wheels (36-hole mavic OP with whatever shimano called their ultegra-esque hubs of the day). I did a bit of comparison. The Alex hubs have a aluminum cassette body (I believe that's what the spline is called where the cassette mounts). It's being eaten by the cassette already. The cassette digs in to the aluminum enough that it can be hard to remove. The shimano is of course stainless or something and fairly bullet proof. I noticed the hub on my rear wheel also seems fairly gritty when I spin it with my fingers. The 10 year old bombers are still great. The bombers are of course heavier.
I took the bomber in to have it trued so I could use it as a training wheel and mentioned the gritty Alex hub. They ended up keeping my Alex wheel to address under warranty. It was almost a given that the stock wheels wouldn't hold up to being ridden by a clyde. They don't.
I'm considering Easton/Velomax Orion II or Circuit II wheels. They are expensive, but I've heard a lot of really good things about them. Opinions?
In the mean time I'll be riding the bomber wheel at least on the rear. I don't care about a little weight if it means I get to just ride without being on eggshells.