I'm 5' 9" and 280lbs. I've been commuting about 4 miles one way to work each day and because I've had such harsh inner thigh muscle fatigue, in the evening I've thrown my bike on the bus and cheated most of the way back home (the incline is slight, but I'm using the easiest granny gear I have and still struggling!). Oh yeah, my hands are killing me too! AND, in the morning, my lower back has been so sore that it is difficult to even get out of bed. Does all of this eventually go away?
How long before you other clydes got your bodies used to riding? Any tips? Motivating stories?