Thought I'd share, as many of us have talked about wheel challenges...and I've been through my share.
By way of background, I'm around 6'4 / 230, and often use the bike to commute (38 miles round trip). So, between me, 2 water bottles, the bike and a bag that includes the laptop, weights can push 270. I'm pretty strong, and have been known to pop wheels out of true when standing to climb, which I do a lot. Bike is a kona JTS, and I have the deep vs as summer / distance wheels. I go through chains every 800 miles, and have in the past broken several spokes, a rim,bent a chaingring and destroyed 2 bottom brackets.
The wheels were handbuilt by SpinLite, and I'm running 36h in the back and 28 in the front, on Ultegra hubs. I clean them when I clean the rest of the bike, and have ridden them in the rain and on dirt trails (hey, it's a cross bike). I'm running 700x28 conti ultra gatorskins. Other than that, I've got reflective tape on the V section to make me more visible at night. I did not have them re-tensioned after 100 miles, as they didn't need it. They are also the first new wheels I've ever had that didn't "pop" when i first rode them.
After 1,000 miles, I figured I'd put the stock wheels back on the bike (wanted more grip on the wet leaves that the 38s on there afford) and bring the wheels to a local wheel builder who has a great reputation. I went by to pick them up last night. His assessment -- perfectly true, in great shape. He upped the tension on the front a little, but that was it.
Getting these has in a way "saved" cycling for me. I used to be tentative, and always look back after a bump or a climb to see how my wheels were. It was no fun, and it actually led me to not ride at times.
These are the stiffest and strongest wheels I've ever ridden, and I've stopped worrying about them. They are heavy, but I kind of like the way they carry momentum. I can't overstate the difference this has made, and the value of a quality hand-build using good parts (rims, spokes, nipples and hubs).