My wrist is really bothering me. I am not blaming it on biking although my wrists do fatigue a little after an hour ride. I ride arms locked position but I am not at all comfortable with bent elbows. I read that the seat should be as high as the handlebars and my seat is much higher than my handlebars. I am about 6'4" and I can not raise my handlebars on my mountainbike. I tape and fold a lot of boxes in the packaging department so I use my wrists there a lot too. I do not do any heavy lifting.