After all reading everything I could find about what the best puncture resistant tire is to ride, I ultimately decided upon the Gatorskins. This wasn't a trivial decision since there is a generous amount of feedback about high rolling resistance and the feeling of a rough ride.
I picked up the ultras, and I have only put one commute on them so far, but I have to say that I personally found all the negative feedback I had read to be unfounded. I am sure they aren't as light as race tires, but the ride was better all the way around from the tires I replaced (some other Continental variety that originally came with the bike when it was new). I had a much smoother ride, felt better in the corners, average speed was close enough to the same that it really didn't matter, and still had the comfort of knowing they were not as susceptible to punctures as what I had been riding.
I kept the tire liners I had been using from the old tires. If I get a puncture with these I will try putting those back in as well and be double protected.
Anyway, to make a long story longer, unless you are some high-performance racer type that is worrying about every single ounce, these tires are great.