I've had two comfort issues recently. First problem was some irritation around the anus. Cycling didn't hurt, but lots of other things did. I went to a doctor, and it turned out to be a yeast infection. I didn't know that happened to guys.
Apparently the warmer weather and more riding teamed up to cause moisture (imagine that!) that led to the problem. I have a prescription cream that is treating it well.
I rode a century ride a week ago, and toward the end of the ride, it felt as if the saddle (Brooks B17) was "off". I looked at it when I got home, and it almost appeared that it had rotated to the left slightly and dropped a few millimeters.
I carefully re-adjusted it before riding this past week.
The first part of the week was more comfortable. Later in the week, I was getting a nasty painful spot near the crease with my leg. It felt like one of the rivets was gouging me through my bike shorts. I inspected the saddle and everything looked fine.
I found the problem while in the shower. I have a zit/cyst/painful bump or something in that spot.
It's not a saddle sore, it not really a weight bearing place, but it does rub the saddle when riding. Short of breaking out the recumbent for commuting (which I may do) how can I treat this thing? I know it'll go away on it's own, but I don't want to stop riding until then.